No evidence of tumorigenicity was noticed in male and female mice at codeine dietary doses around four hundred mg/kg/day (approximately akin to 45 situations the MRHD on a mg/m2 basis).

Observational research have demonstrated that concomitant utilization of opioid analgesics and benzodiazepines increases the chance of drug-associated mortality in comparison to utilization of opioids by yourself.

Chosen from knowledge incorporated with permission and copyrighted by To start with Databank, Inc. This copyrighted material is downloaded from a certified facts provider and is not for distribution, apart from as could be approved because of the applicable terms of use.

The concomitant usage of Promethazine HCl and Codeine Phosphate Oral Resolution with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor may cause reduced codeine levels, higher norcodeine amounts, and less metabolism by way of 2D6 with resultant lessen morphine ranges.

Narcotics may possibly generate adverse reactions which may obscure the clinical class of individuals with head accidents.

The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients under six several years of age. Concomitant administration of promethazine solutions with other respiratory depressants has an Affiliation with respiratory despair, and from time to time death, in pediatric individuals. The association does indirectly relate to individualized excess weight-dependent dosing, which could normally permit safe administration.

Stay clear of the use of Promethazine HCl and Codeine Phosphate Oral Answer in adolescents 12 to eighteen decades of age who produce other danger things that will boost their sensitivity into the respiratory depressant outcomes of codeine. Risk things involve problems affiliated with hypoventilation, like postoperative standing, obstructive snooze apnea, weight problems, severe pulmonary disorder, neuromuscular disease, and concomitant usage of other medicines that lead to respiratory depression.

Your mouth may well get dry. Chewing sugarless gum or sucking difficult sweet and drinking lots of drinking water may possibly support. Contact your treatment group if the condition won't go away or is severe.

Narcotic analgesics, which includes codeine, exert their Most important consequences about the central anxious system and gastrointestinal tract. The analgesic outcomes of codeine are as a consequence of its central action; nonetheless, the specific sites of action have not been decided, as well as the mechanisms associated seem like very elaborate.

Consequences about the Gastrointestinal Tract along with other Smooth Muscle Codeine leads to a discount in motility related to an increase in sleek muscle tone in the antrum on the belly and duodenum. Digestion of food items from the small intestine is delayed and propulsive contractions are reduced.

Get medical support at once should you observe any of the subsequent: slow/shallow respiration, extreme drowsiness/trouble waking up, confusion.

Postmarketing conditions of respiratory despair, together with fatalities happen to be reported with usage of promethazine in pediatric patients.

It's not an entire list of achievable Negative effects. For those who discover other Unwanted side effects not detailed earlier mentioned, Make contact with Promethazine codeine syrup your health care provider or pharmacist.

Codeine and promethazine, two in the Energetic elements in Promethazine HCl and Codeine Phosphate Oral Remedy, could develop marked drowsiness and impair the mental and/or physical talents essential for that overall performance of doubtless harmful responsibilities for example driving a vehicle or working machinery. Suggest clients to stay away from engaging in hazardous jobs requiring psychological alertness and motor coordination soon after ingestion of Promethazine HCl and Codeine Phosphate Oral Resolution.